Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
Identifieur interne : 000947 ( Main/Exploration ); précédent : 000946; suivant : 000948Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
Auteurs : A. C. Ludolph [Allemagne] ; J. Kassubek [Allemagne] ; B. G. Landwehrmeyer [Allemagne] ; E. Mandelkow [Allemagne] ; E. Mandelkow [Allemagne] ; D. J. Burn [Royaume-Uni] ; D. Caparros-Lefebvre [France] ; K. A. Frey [États-Unis] ; J. G. De Yebenes [Espagne] ; T. Gasser [Allemagne] ; P. Heutink [Pays-Bas] ; G. Höglinger [Allemagne] ; Z. Jamrozik [Pologne] ; K. A. Jellinger [Autriche] ; A. Kazantsev [États-Unis] ; H. Kretzschmar [Allemagne] ; A. E. Lang [Canada] ; I. Litvan [États-Unis] ; J. J. Lucas [Espagne] ; P. L. Mcgeer [Canada] ; S. Melquist [États-Unis] ; W. Oertel [Allemagne] ; M. Otto [Allemagne] ; D. Paviour [Royaume-Uni] ; T. Reum [Allemagne] ; A. Saint-Raymond [Royaume-Uni] ; J. C. Steele ; M. Tolnay [Suisse] ; H. Tumani [Allemagne] ; J. C. Van Swieten [Pays-Bas] ; M. T. Vanier [France] ; J. Vonsattel [États-Unis] ; S. Wagner [Allemagne] ; Z. K. Wszolek [États-Unis]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2009-03.
English descriptors
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Abstract
Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease‐modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann‐Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.
Url:
DOI: 10.1111/j.1468-1331.2008.02513.x
Affiliations:
- Allemagne, Autriche, Canada, Espagne, France, Pays-Bas, Pologne, Royaume-Uni, Suisse, États-Unis
- Angleterre, Bade-Wurtemberg, Bavière, Communauté de Madrid, District de Cologne, District de Giessen, District de Haute-Bavière, District de Leipzig, District de Tübingen, Floride, Hambourg, Hesse (Land), Hollande-Septentrionale, Kentucky, Massachusetts, Michigan, Rhénanie-du-Nord-Westphalie, Saxe (Land), Vienne (Autriche), État de New York
- Amsterdam, Bonn, Hambourg, Leipzig, Lyon, Madrid, Marbourg, Munich, New York, Tübingen, Ulm, Valenciennes, Vienne (Autriche)
- Université Columbia, Université d'Ulm
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Caparros-Lefebvre</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier de Valenciennes, Résidence du Val d’Escaut, Avenue Desandrouin, Valenciennes</wicri:regionArea><placeName><settlement type="city">Valenciennes</settlement></placeName></affiliation></author><author><name sortKey="Frey, K A" sort="Frey, K A" uniqKey="Frey K" first="K. A." last="Frey">K. A. Frey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="De Yebenes, J G" sort="De Yebenes, J G" uniqKey="De Yebenes J" first="J. G." last="De Yebenes">J. G. De Yebenes</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ramon y Cajal, Neurology, Carretera Colmenar, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T." last="Gasser">T. Gasser</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Tübingen, Zentrum für Neurologie, Hoppe‐Seyler‐Strasse, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P." last="Heutink">P. Heutink</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Department of Clinical Genetics and Anthropogenet, van der Boechorststraat, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hoglinger, G" sort="Hoglinger, G" uniqKey="Hoglinger G" first="G." last="Höglinger">G. Höglinger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Jamrozik, Z" sort="Jamrozik, Z" uniqKey="Jamrozik Z" first="Z." last="Jamrozik">Z. Jamrozik</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Medical University of Warsaw, Neurology, Banacha, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Jellinger, K A" sort="Jellinger, K A" uniqKey="Jellinger K" first="K. A." last="Jellinger">K. A. Jellinger</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Clinical Neurobiology, Kenyongasse, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Kazantsev, A" sort="Kazantsev, A" uniqKey="Kazantsev A" first="A." last="Kazantsev">A. Kazantsev</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, MIND/Harvard Medical School, Charlestown, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kretzschmar, H" sort="Kretzschmar, H" uniqKey="Kretzschmar H" first="H." last="Kretzschmar">H. Kretzschmar</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Neuropathologie, BrainNet (German Brain Bank), Feodor‐Lynen‐Strasse, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Hospital, Movement Disorders Center, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Louisville, School of Medicine/Department of Neurology, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Lucas, J J" sort="Lucas, J J" uniqKey="Lucas J" first="J. J." last="Lucas">J. J. Lucas</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Biologica Molecular “Severo Ochoa,” Universidad Autonoma de Madrid and CiberNed, Cantoblanco, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Melquist, S" sort="Melquist, S" uniqKey="Melquist S" first="S." last="Melquist">S. Melquist</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Department of Neuroscience, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Oertel, W" sort="Oertel, W" uniqKey="Oertel W" first="W." last="Oertel">W. Oertel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Philipps‐Universität, Neurologie, Rudolf‐Bultmann‐Strasse, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M." last="Otto">M. Otto</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Paviour, D" sort="Paviour, D" uniqKey="Paviour D" first="D." last="Paviour">D. Paviour</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>National Hospital for Neurology, Dementia Research Centre, London</wicri:cityArea></affiliation></author><author><name sortKey="Reum, T" sort="Reum, T" uniqKey="Reum T" first="T." last="Reum">T. Reum</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bundesinstitut für Arzneimittel & Medizinprodukte, Wissenschaftlicher Service/Klinische Prüfungen, Georg‐Kiesinger‐Allee, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Saint Aymond, A" sort="Saint Aymond, A" uniqKey="Saint Aymond A" first="A." last="Saint-Raymond">A. Saint-Raymond</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>European Medicines Agency (EMEA), Scientific Advice and Orphan Drugs Sector, 7 Westferry Circus, Canary Wharf, London</wicri:cityArea></affiliation></author><author><name sortKey="Steele, J C" sort="Steele, J C" uniqKey="Steele J" first="J. C." last="Steele">J. C. Steele</name><affiliation><wicri:noCountry code="subField">Guam</wicri:noCountry></affiliation></author><author><name sortKey="Tolnay, M" sort="Tolnay, M" uniqKey="Tolnay M" first="M." last="Tolnay">M. Tolnay</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institut für Pathologie, Schönbeinstrasse, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tumani, H" sort="Tumani, H" uniqKey="Tumani H" first="H." last="Tumani">H. Tumani</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J. C." last="Van Swieten">J. C. Van Swieten</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University Hospital Rotterdam, Department of Neurology, Erasmus MC, Dr Molewaterplein, GD Rotterdam</wicri:regionArea><wicri:noRegion>GD Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Vanier, M T" sort="Vanier, M T" uniqKey="Vanier M" first="M. T." last="Vanier">M. T. Vanier</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Unit 820, Laënnec Medical School, Lyon</wicri:regionArea><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Vonsattel, J" sort="Vonsattel, J" uniqKey="Vonsattel J" first="J." last="Vonsattel">J. Vonsattel</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York Brain Bank, Columbia University, Pathology, Babies Hospital, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Wagner, S" sort="Wagner, S" uniqKey="Wagner S" first="S." last="Wagner">S. Wagner</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsche PSP‐Gesellschaft e.V. (PSP Germany), c/o S. Wagner, Könneritzstrasse, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Wszolek, Z K" sort="Wszolek, Z K" uniqKey="Wszolek Z" first="Z. K." last="Wszolek">Z. K. Wszolek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Department of Neurology, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-03">2009-03</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="297">297</biblScope><biblScope unit="page" to="309">309</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">46DA66675464C537825E2DA84B0B1D58DE536F61</idno><idno type="DOI">10.1111/j.1468-1331.2008.02513.x</idno><idno type="ArticleID">ENE2513</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term><term>corticobasal degeneration</term><term>frontotemporal dementia with parkinsonism linked to chromosome 17</term><term>microtubule‐associated protein tau</term><term>multiple system atrophy</term><term>parkinsonism</term><term>progressive supranuclear palsy</term><term>tauopathies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease‐modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann‐Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Canada</li><li>Espagne</li><li>France</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Bavière</li><li>Communauté de Madrid</li><li>District de Cologne</li><li>District de Giessen</li><li>District de Haute-Bavière</li><li>District de Leipzig</li><li>District de Tübingen</li><li>Floride</li><li>Hambourg</li><li>Hesse (Land)</li><li>Hollande-Septentrionale</li><li>Kentucky</li><li>Massachusetts</li><li>Michigan</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe (Land)</li><li>Vienne (Autriche)</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Bonn</li><li>Hambourg</li><li>Leipzig</li><li>Lyon</li><li>Madrid</li><li>Marbourg</li><li>Munich</li><li>New York</li><li>Tübingen</li><li>Ulm</li><li>Valenciennes</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université Columbia</li><li>Université d'Ulm</li></orgName></list><tree><noCountry><name sortKey="Steele, J C" sort="Steele, J C" uniqKey="Steele J" first="J. C." last="Steele">J. C. Steele</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Ludolph, A C" sort="Ludolph, A C" uniqKey="Ludolph A" first="A. C." last="Ludolph">A. C. Ludolph</name></region><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T." last="Gasser">T. Gasser</name><name sortKey="Hoglinger, G" sort="Hoglinger, G" uniqKey="Hoglinger G" first="G." last="Höglinger">G. Höglinger</name><name sortKey="Kassubek, J" sort="Kassubek, J" uniqKey="Kassubek J" first="J." last="Kassubek">J. Kassubek</name><name sortKey="Kretzschmar, H" sort="Kretzschmar, H" uniqKey="Kretzschmar H" first="H." last="Kretzschmar">H. Kretzschmar</name><name sortKey="Landwehrmeyer, B G" sort="Landwehrmeyer, B G" uniqKey="Landwehrmeyer B" first="B. G." last="Landwehrmeyer">B. G. Landwehrmeyer</name><name sortKey="Mandelkow, E" sort="Mandelkow, E" uniqKey="Mandelkow E" first="E." last="Mandelkow">E. Mandelkow</name><name sortKey="Mandelkow, E" sort="Mandelkow, E" uniqKey="Mandelkow E" first="E." last="Mandelkow">E. Mandelkow</name><name sortKey="Oertel, W" sort="Oertel, W" uniqKey="Oertel W" first="W." last="Oertel">W. Oertel</name><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M." last="Otto">M. Otto</name><name sortKey="Reum, T" sort="Reum, T" uniqKey="Reum T" first="T." last="Reum">T. Reum</name><name sortKey="Tumani, H" sort="Tumani, H" uniqKey="Tumani H" first="H." last="Tumani">H. Tumani</name><name sortKey="Wagner, S" sort="Wagner, S" uniqKey="Wagner S" first="S." last="Wagner">S. Wagner</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name></noRegion><name sortKey="Paviour, D" sort="Paviour, D" uniqKey="Paviour D" first="D." last="Paviour">D. Paviour</name><name sortKey="Saint Aymond, A" sort="Saint Aymond, A" uniqKey="Saint Aymond A" first="A." last="Saint-Raymond">A. Saint-Raymond</name></country><country name="France"><noRegion><name sortKey="Caparros Efebvre, D" sort="Caparros Efebvre, D" uniqKey="Caparros Efebvre D" first="D." last="Caparros-Lefebvre">D. Caparros-Lefebvre</name></noRegion><name sortKey="Vanier, M T" sort="Vanier, M T" uniqKey="Vanier M" first="M. T." last="Vanier">M. T. Vanier</name></country><country name="États-Unis"><region name="Michigan"><name sortKey="Frey, K A" sort="Frey, K A" uniqKey="Frey K" first="K. A." last="Frey">K. A. Frey</name></region><name sortKey="Kazantsev, A" sort="Kazantsev, A" uniqKey="Kazantsev A" first="A." last="Kazantsev">A. Kazantsev</name><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name><name sortKey="Melquist, S" sort="Melquist, S" uniqKey="Melquist S" first="S." last="Melquist">S. Melquist</name><name sortKey="Vonsattel, J" sort="Vonsattel, J" uniqKey="Vonsattel J" first="J." last="Vonsattel">J. Vonsattel</name><name sortKey="Wszolek, Z K" sort="Wszolek, Z K" uniqKey="Wszolek Z" first="Z. K." last="Wszolek">Z. K. Wszolek</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="De Yebenes, J G" sort="De Yebenes, J G" uniqKey="De Yebenes J" first="J. G." last="De Yebenes">J. G. De Yebenes</name></region><name sortKey="Lucas, J J" sort="Lucas, J J" uniqKey="Lucas J" first="J. J." last="Lucas">J. J. Lucas</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Heutink, P" sort="Heutink, P" uniqKey="Heutink P" first="P." last="Heutink">P. Heutink</name></region><name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J. C." last="Van Swieten">J. C. Van Swieten</name></country><country name="Pologne"><noRegion><name sortKey="Jamrozik, Z" sort="Jamrozik, Z" uniqKey="Jamrozik Z" first="Z." last="Jamrozik">Z. Jamrozik</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Jellinger, K A" sort="Jellinger, K A" uniqKey="Jellinger K" first="K. A." last="Jellinger">K. A. Jellinger</name></region></country><country name="Canada"><noRegion><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name></noRegion><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name></country><country name="Suisse"><noRegion><name sortKey="Tolnay, M" sort="Tolnay, M" uniqKey="Tolnay M" first="M." last="Tolnay">M. Tolnay</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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